PD-1+ melanocortin receptor dependent-Treg cells prevent autoimmune disease
نویسندگان
چکیده
منابع مشابه
Treg suppressive activity involves estrogen-dependent expression of programmed death-1 (PD-1).
Estrogen [17-beta-estradiol (E2)] is a potent driver of the FoxP3+ regulatory T cell (Treg) compartment. Recently, Tregs were further characterized by intracellular expression of the negative co-stimulatory molecule, programmed death-1 (PD-1). To clarify the role of PD-1 versus FoxP3 in E2-enhanced Treg suppression, we evaluated both markers and functional suppression in wild-type, estrogen rec...
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ژورنال
عنوان ژورنال: Scientific Reports
سال: 2019
ISSN: 2045-2322
DOI: 10.1038/s41598-019-53297-w